Beilstein J. Org. Chem.2017,13, 441–450, doi:10.3762/bjoc.13.47
valine and its C-methylation with methionine and the polyol carbons are derived from a glycolysis intermediate, possibly hydroxymalonyl-ACP.
Keywords: biosynthesis; butyrolactol; contiguouspolyol; hydroxymalonyl-ACP; polyketide; Streptomyces; tert-butyl; Introduction
Actinomycetes produce structurally
to C-4) and the pentaol (C-5 to C-9) moieties (Figure 3), suggesting that the contiguouspolyol system is not formed by methylene hydroxylation. Another possible pathway for 1,2-diol formation is the incorporation of hydroxymalonyl-ACP from a glycolytic intermediate for chain elongation [23]. To
experimentally identified the precursor of a tert-butyl group in a polyketide backbone. The unusual contiguouspolyol system comprising eight hydroxylated carbons was proved to be arising from the chain extension using hydroxymalonyl-ACP by labeling experiments of [1,2-13C2]acetate and [U-13C6]glucose. This